US 12,275,771 B2
Relaxin immunoglobulin fusion proteins and methods of use
Feng Wang, Carlsbad, CA (US); Yan Liu, San Diego, CA (US); Ying Wang, San Diego, CA (US); Guangsen Fu, San Diego, CA (US); and Peter G. Schultz, La Jolla, CA (US)
Assigned to THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US)
Filed by The Scripps Research Institute, La Jolla, CA (US)
Filed on Aug. 26, 2021, as Appl. No. 17/458,136.
Application 17/458,136 is a continuation of application No. 16/060,384, granted, now 11,161,891, previously published as PCT/US2016/065779, filed on Dec. 9, 2016.
Claims priority of provisional application 62/265,344, filed on Dec. 9, 2015.
Prior Publication US 2022/0048969 A1, Feb. 17, 2022
Int. Cl. C07K 14/64 (2006.01); A61K 9/00 (2006.01); A61K 9/02 (2006.01); A61K 9/10 (2006.01); A61P 11/00 (2006.01); A61P 13/12 (2006.01); C07K 16/10 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/64 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0048 (2013.01); A61K 9/02 (2013.01); A61K 9/10 (2013.01); A61P 11/00 (2018.01); A61P 13/12 (2018.01); C07K 16/1027 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)] 22 Claims
 
1. An antibody comprising a light chain comprising light chain complementarity determining regions CDRL1, CDRL2, and CDRL3, and a heavy chain comprising heavy chain complementarity determining regions CDRH1, CDRH2, and CDRH3, wherein:
the CDRL1 comprises the amino acid sequence of SEQ ID NO: 89 (KCQLSVGYMH),
the CDRL2 comprises the amino acid sequence of SEQ ID NO: 90 (DTSKLAS),
the CDRL3 comprises the amino acid sequence of SEQ ID NO: 96 (FQGNGYPFT),
the CDRH1 comprises the amino acid sequence of SEQ ID NO: 72 (TFSGFSLSTSGMSVG),
the CDRH2 comprises the amino acid sequence of SEQ ID NO: 73 (DIWWDDKKDYNPSLKS),
and the CDRH3 comprises the amino acid sequence of SEQ ID NO: 79 (SMITFGGFDV).