US 12,275,755 B2
All-trans polyene amphoteric macrolide
Alexander Lucia Leonardus Duchateau, Echt (NL); Peter Philip Lankhorst, Echt (NL); and Willebrordus Bernardus Van Scheppingen, Echt (NL)
Assigned to DSM IP ASSETS B.V., Heerlen (NL)
Filed by DSM IP ASSETS B.V., Heerlen (NL)
Filed on Feb. 6, 2023, as Appl. No. 18/164,743.
Application 18/164,743 is a continuation of application No. 17/267,790, granted, now 11,623,939, previously published as PCT/EP2019/071899, filed on Aug. 15, 2019.
Claims priority of application No. 18189251 (EP), filed on Aug. 16, 2018.
Prior Publication US 2023/0183285 A1, Jun. 15, 2023
Int. Cl. C07H 17/08 (2006.01); C07H 1/06 (2006.01)
CPC C07H 17/08 (2013.01) [C07H 1/06 (2013.01)] 5 Claims
 
1. A composition comprising natamycin, water and a compound of formula II comprising (1R,3S,5E,7R,11R,13E,15E,17E, 19E,21R,23S,24R,25S)-21-[(3-Amino-3,6-dideoxy-β-d-mannopyranosyl)oxy]-1,3,7,25-tetrahydroxy-11-methyl-9-oxo-10,27-dioxabicyclo[21.3.1]heptacosa-5,13,15,17,19-pentaene-24-carboxylic acid of formula (II) or a salt thereof

OG Complex Work Unit Chemistry
wherein the composition further comprises a compound of formula (III)
(1R,3S,5R,7R,8E,12R,14Z,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-β-d-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, wherein the amount of said compound of formula (III) or salt thereof is from 0.001-0.1% (w/w) relative to the amount of natamycin

OG Complex Work Unit Chemistry