| CPC C07D 491/22 (2013.01) | 31 Claims |
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1. A method of treating a ROS1 or ALK positive cancer, wherein the cancer is lung cancer, glioblastoma, inflammatory myofibroblastic tumor (IMT), bile duct cancer, ovarian cancer, gastric cancer, colorectal cancer, angiosarcoma, melanoma, epithelioid hemangioendothelioma, esophageal cancer, kidney cancer, breast cancer, colon cancer, thyroid cancer, spitzoid tumor, or neuroblastoma, wherein the method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
 or an enantiomer, a mixture of enantiomers, or a tautomer thereof, or a pharmaceutically acceptable salt thereof,
wherein:
Q is CH;
Z is CR5;
X is a 5-membered heteroarylene selected from the group consisting of
 wherein * indicates the point of attachment of X to the methylene group bonded to X and Y;
Y is a 5-membered heteroarylene selected from the group consisting of
 wherein * indicates the point of attachment of Y to the methylene group bonded to X and Y;
R1 is selected from the group consisting of H, methyl, and hydroxymethyl;
each instance of R2 is independently selected from the group consisting of H, CN, halo, C1-4 alkoxy, C1-4 alkyl, halo-C1-4 alkyl, C3-4 cycloalkylmethyl, C3-6 cycloalkyl, and three- to six-membered heterocyclyl;
each instance of R3 is independently selected from the group consisting of H, halo, CN, C1-4 alkoxy, halo-C1-4 alkyl, and C1-4 alkyl; and
each of R4 and R5 is independently H or F.
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