US 12,275,740 B2
Method of inhibiting kinase by camsylate salts of triazolopyrazine derivatives
Jun Young Choi, Seoul (KR); Kyung-eui Park, Seoul (KR); and Na Young Kim, Seoul (KR)
Filed by ABION Inc., Seoul (KR)
Filed on Dec. 26, 2023, as Appl. No. 18/395,739.
Application 18/395,739 is a division of application No. 17/849,784, filed on Jun. 27, 2022, granted, now 11,964,979.
Prior Publication US 2024/0124472 A1, Apr. 18, 2024
Int. Cl. C07D 487/04 (2006.01)
CPC C07D 487/04 (2013.01) 5 Claims
 
1. A method of inhibiting the activity of c-Met kinase in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a camsylate salt of the compound of formula (1):

OG Complex Work Unit Chemistry
wherein the camsylate salt has an HT-XRPD pattern with characteristic peaks corresponding substantially to:
 
 
 2θ [°] d [Å] Intensity or
 
 2θ [°] d [Å] Intensity
 
 
1 6.29 14.04 31
 
 1 6.34 13.92 22
2 10.31 8.57 38
 
 2 10.36 8.53 28
3 12.20 7.25 45
 
 3 12.03 7.35 28
4 13.70 6.46 41
 
 4 12.26 7.21 28
5 14.32 6.18 94
 
 5 13.80 6.41 42
6 15.54 5.70 60
 
 6 14.33 6.18 100
7 16.92 5.24 100
 
 7 14.94 5.92 39
8 18.19 4.87 35
 
 8 15.52 5.70 46
9 20.12 4.41 46
 
 9 16.83 5.26 72
10 21.57 4.12 43
 
 10 18.26 4.85 27
11 23.36 3.81 31
 
 11 20.11 4.41 33
12 24.19 3.68 37
 
 12 21.14 4.20 25
13 26.46 3.37 26
 
 13 21.42 4.14 28
14 27.79 3.21 23
 
 14 22.35 3.98 21
15 28.84 3.09 21
 
 15 23.42 3.80 24
16 29.50 3.03 22
 
 16 23.92 3.72 24
 
 
 
 
 
 17 26.38 3.38 18
 
 
 
 
 
 18 27.92 3.19 16
 
 
 
 
 
 19 28.83 3.09 19
 
 
 
 
 
 20 29.59 3.02 15.