US 12,275,725 B2
Inhibitors of the notch transcriptional activation complex and methods for use of the same
Anthony J. Capobianco, Miami Beach, FL (US); Mark Spyvee, Hampstead, NH (US); Luisana Astudillo, North Miami, FL (US); and Darren Orton, Miami, FL (US)
Assigned to University of Miami, Miami, FL (US); and StemSynergy Therapeutics, Inc., Miami, FL (US)
Appl. No. 17/602,311
Filed by University of Miami, Miami, FL (US); and StemSynergy Therapeutics, Inc., Miami, FL (US)
PCT Filed Feb. 11, 2020, PCT No. PCT/US2020/017685
§ 371(c)(1), (2) Date Oct. 8, 2021,
PCT Pub. No. WO2020/209933, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/832,538, filed on Apr. 11, 2019.
Prior Publication US 2022/0194932 A1, Jun. 23, 2022
Int. Cl. C07D 417/12 (2006.01); A61P 35/00 (2006.01); C07D 403/12 (2006.01)
CPC C07D 417/12 (2013.01) [A61P 35/00 (2018.01); C07D 403/12 (2013.01)] 20 Claims
 
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein:
n is 1 or 2;
Y is O, S or NC1-3alkyl;
Z is triazolyl;
R1 is H or C1-3alkyl;
R2 is H or C1-3alkyl; and
R3 is C1-3alkyl or halophenyl.