| CPC B29C 59/022 (2013.01) [A61M 25/1027 (2013.01); B29C 33/40 (2013.01); B29C 33/424 (2013.01); B29C 33/56 (2013.01); B29C 37/0032 (2013.01); B29C 59/021 (2013.01); B29C 59/06 (2013.01); G03F 7/0002 (2013.01); A61M 2025/1031 (2013.01); B29C 2033/426 (2013.01); B29C 2037/0035 (2013.01); B29C 2059/023 (2013.01); B29K 2083/00 (2013.01); B29K 2875/00 (2013.01)] | 21 Claims |

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1. A method of patterning a biocompatible three-dimensional (3D) object, comprising:
wrapping a flexible stamp around the 3D object, the flexible stamp having a micropattern on a micropatterned side, the flexible stamp being conformable to a surface of the 3D object;
inserting the 3D object wrapped in the flexible stamp into a vacuum bag such that the micropatterned side of the flexible stamp faces the surface of the 3D object; and
applying vacuum to the 3D object and the flexible stamp within the vacuum bag to induce a differential pressure between inside and outside of the vacuum bag to cause the vacuum bag to press inward against the flexible stamp and thereby conform the flexible stamp to the surface of the 3D object to transfer the micropattern of the flexible stamp to the surface of the 3D object;
wherein the flexible stamp is a flat sheet with a thickness that is no greater than 500 microns.
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