US 12,275,008 B2
Electronic-sensing and magnetic-modulation (ESMM) biosensor for phagocytosis quantification in pathogenic infections and methods of use thereof
Umer Hassan, Monmouth Junction, NJ (US); and Corey Norton, Lodi, NJ (US)
Assigned to Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed by Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed on Feb. 12, 2024, as Appl. No. 18/438,938.
Application 18/438,938 is a continuation of application No. 17/519,223, filed on Nov. 4, 2021, granted, now 11,951,476.
Claims priority of provisional application 63/116,236, filed on Nov. 20, 2020.
Claims priority of provisional application 63/115,647, filed on Nov. 19, 2020.
Prior Publication US 2024/0181448 A1, Jun. 6, 2024
Int. Cl. B01L 3/00 (2006.01); B01F 33/302 (2022.01); B01F 33/3033 (2022.01); B01L 7/00 (2006.01); C12Q 1/6848 (2018.01); C12Q 1/686 (2018.01); G01N 21/29 (2006.01); G01N 21/65 (2006.01); G01N 33/574 (2006.01); G01N 33/58 (2006.01); G01N 35/00 (2006.01); G03F 7/00 (2006.01); G03F 7/038 (2006.01); G03F 7/20 (2006.01); G03F 7/32 (2006.01); G06N 3/08 (2023.01); G06N 20/00 (2019.01); H01F 1/053 (2006.01); H01F 7/02 (2006.01)
CPC B01L 3/502715 (2013.01) [B01L 3/502707 (2013.01); G01N 35/0098 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0883 (2013.01); G03F 7/0037 (2013.01); G03F 7/0382 (2013.01); G03F 7/2004 (2013.01); G03F 7/322 (2013.01); G06N 3/08 (2013.01); G06N 20/00 (2019.01); H01F 1/053 (2013.01); H01F 7/02 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A device, comprising:
a substrate;
an electrical subsystem of at least two electrodes,
wherein the at least two electrodes are disposed on the substrate,
wherein the at least two electrodes are configured to generate an electric field;
at least one sensing region,
wherein the at least one sensing region comprises the electrical subsystem;
a microfluidic subsystem of a microfluidic channel comprising at least one inlet and an outlet,
wherein at least a portion of the microfluidic channel is disposed in proximity of the at least two electrodes on the substrate; and
a magnetic subsystem of at least one magnet,
wherein the at least one magnet is disposed adjacent to the microfluidic channel, and
wherein the at least one magnet is configured to provide a magnetic field in at least a portion of the microfluidic channel,
wherein the at least one magnet is adjacent to the at least one sensing region,
wherein an edge of the at least one magnet is upstream of the at least one sensing region,
wherein the at least one portion of the microfluidic channel of the device is configured to comprise the electric field generated by the at least two electrodes and the magnetic field generated by the at least one magnet.