CPC A61K 47/6889 (2017.08) [A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61K 47/6851 (2017.08); A61K 47/6883 (2017.08); A61P 31/00 (2018.01); C07D 519/00 (2013.01)] | 19 Claims |
1. A compound having the structure of Formula (I):
![]() or a pharmaceutically acceptable salt thereof,
wherein:
Ring A is selected from:
![]() each Ra1 is independently selected from H and alkyl;
each Ra2 is independently selected from H, halogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Ring B is selected from:
![]() each Rb1 is independently selected from H and alkyl;
each Rb2 is independently selected from H, halogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
each Rb3 is independently selected from H, halogen, cyano, nitro, alkyl, CH2N(CH3)2, NRARA, N+RARARA, OH, O(alkyl), SH, S(alkyl), cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
each Rc is independently selected from H, halogen, cyano, alkyl, CH2N(CH3)2, NRARA, N+RARARA, OH, aryl, and heteroaryl, wherein each aryl and heteroaryl is optionally and independently substituted with one or more substituents independently selected from the group consisting of H, halogen, cyano, alkyl, CH2N(CH3)2, NRARA, N+RARARA, OH, O(alkyl), SH, S(alkyl), and aryl;
Rc′ is selected from H, halogen, cyano, alkyl, alkylidenyl, NRARA, N+RARARA, OH, aryl, and heteroaryl, wherein the aryl or heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of H, halogen, cyano, alkyl, CH2N(CH3)2, NRARA, N+RARARA, OH, O(alkyl), SH, S(alkyl), and aryl;
Z1 is
![]() each Y1 is independently CRY1;
each RY1 is independently selected from H, (CH2)yRY1a, C(O)NRARA, NRARA, N+RARARA, and OH;
each RY1a is independently selected from NRARA, N+RARARA, aryl, and heteroaryl;
each y is independently selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
R1 is alkyl;
R2 is alkyl;
each RA is independently selected from H and alkyl;
na is 1;
n1 is 1; and
n2 is 1.
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