US 12,274,792 B2
Method for automatically producing individualized tablets, and tablet press for automatically producing individualized tablets
Ingo Krause, Scharbeutz (DE)
Assigned to PrivMed X AB, Akersberga (SE)
Filed by PrivMed X AB, Akersberga (SE)
Filed on May 11, 2021, as Appl. No. 17/316,857.
Application 17/316,857 is a continuation of application No. PCT/EP2019/080994, filed on Nov. 12, 2019.
Claims priority of application No. 18205665 (EP), filed on Nov. 12, 2018.
Prior Publication US 2021/0267905 A1, Sep. 2, 2021
Int. Cl. A61K 9/20 (2006.01); A61J 3/06 (2006.01); B30B 11/00 (2006.01); B30B 11/02 (2006.01); B30B 11/04 (2006.01); B30B 15/02 (2006.01); B30B 15/26 (2006.01)
CPC A61K 9/2095 (2013.01) [A61J 3/06 (2013.01); B30B 11/005 (2013.01); B30B 11/025 (2013.01); B30B 11/04 (2013.01); B30B 15/028 (2013.01); B30B 15/26 (2013.01)] 19 Claims
 
1. A method for automatically producing a specifiable number of individualized tablets with a specifiable quantity of a first active substance using a tablet press, the method comprising:
inputting a target number which indicates the number of tablets to be produced and a target mass which indicates the quantity of the first active substance per tablet into an input device of the tablet press, transmitting the target number and the target mass from the input device to a controller configured to control the tablet press, wherein the controller controls a first dosing device of a first material container, a vertically extendable upper punch, and a vertically extendable lower punch, wherein the lower punch comprises only a single lower punch,
filling a quantity of the first active substance which corresponds to the target mass from the first material container into a central opening of a die using the first dosing device, wherein a pressure face of the lower punch, an outer circumference of which corresponds to an inner circumference of the central opening, closes the central opening from below,
selectively moving the upper punch and the first dosing device in a horizontal direction within the tablet press to move the upper punch and the first dosing device above the central opening of the die disposed above the single lower punch while the die and the single lower punch remain stationary in the tablet press and fixed in the horizontal direction;
pressing the first active substance by vertically extending a pressure face of the upper punch, an outer circumference of which corresponds to the inner circumference of the central opening, into the central opening from above,
releasing a pressed tablet from the die by retracting the pressure face of the upper punch and vertically extending a pressure face of the lower punch through the central opening from below, and
repeating the filling of the quantity of the first active substance, the pressing of the first active substance, and the releasing of the pressed tablet until the number of pressed tablets corresponds to the target number.