	US 12,274,758 B2
	Guide RNA that targets a mutant human inosine monophosphate deyhydrogenase I allele
Lior Izhar, Tel Aviv (IL); David Baram, Nir Zvi (IL); Joe Georgeson, Rehevot (IL); Michal Golan-Mashiach, Ness-Ziona (IL); Asael Herman, Ness-Ziona (IL); and Rafi Emmanuel, Ramla (IL)
Assigned to EmendoBio Inc., Wilmington, DE (US)
Filed by EmendoBio Inc., Wilmington, DE (US)
Filed on Nov. 28, 2018, as Appl. No. 16/203,056.
Claims priority of provisional application 62/680,481, filed on Jun. 4, 2018.
Claims priority of provisional application 62/591,344, filed on Nov. 28, 2017.
Prior Publication US 2023/0173107 A1, Jun. 8, 2023
Int. Cl. C12N 15/11 (2006.01); A61K 48/00 (2006.01); A61P 27/00 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01)

CPC A61K 48/0066 (2013.01) [A61P 27/00 (2018.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/1137 (2013.01); C12Y 301/00 (2013.01)]

6 Claims

1. An isolated guide RNA (gRNA) that targets a mutant Inosine Monophosphate Dehydrogenase 1 (IMPDH1) allele, wherein the gRNA comprises a CRISPR RNA (crRNA) consisting of the nucleic acid sequence of SEQ ID NO: 159, 160, 161, 274, 276, 282, 3011, 3012, 3013, 3014, or 3015.