	US 12,274,757 B2
	Recombinant adeno-associated viruses encoding serpin peptides and uses thereof
Alexandra Rose Lucas, Tempe, AZ (US); Alfred S. Lewin, Gainesville, FL (US); and Cristhian J. Ildefonso, Gainesville, FL (US)
Assigned to University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
Appl. No. 16/978,800
Filed by University of Florida Research Foundation, Incorporated, Gainesville, FL (US)
PCT Filed Mar. 8, 2019, PCT No. PCT/US2019/021340 § 371(c)(1), (2) Date Sep. 8, 2020, PCT Pub. No. WO2019/021340, PCT Pub. Date Sep. 12, 2019.
Claims priority of provisional application 62/640,599, filed on Mar. 9, 2018.
Prior Publication US 2021/0000973 A1, Jan. 7, 2021
Int. Cl. A61K 48/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 37/06 (2006.01); C07K 14/81 (2006.01); C12N 15/86 (2006.01)

CPC A61K 48/005 (2013.01) [A61K 48/0075 (2013.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); A61P 37/06 (2018.01); C07K 14/81 (2013.01); C12N 15/86 (2013.01); C12N 2750/14123 (2013.01); C12N 2750/14143 (2013.01)]

15 Claims

1. A recombinant adeno-associated virus (rAAV) vector comprising an isolated nucleic acid encoding a serine proteinase inhibitor 1 (Serp-1) peptide, flanked by two adeno-associated virus (AAV) inverted terminal repeat (ITR) sequences, wherein the rAAV vector comprises the nucleic acid sequence set forth in any one of SEQ ID NOs: 2-4.