	US 12,274,744 B2
	Biomaterials for modulating immune responses
David J. Mooney, Sudbury, MA (US); Aileen Weiwei Li, Norcross, GA (US); Omar Abdel-Rahman Ali, Oakland, CA (US); and Ting-Yu Shih, Brookline, MA (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US)
Filed on Jan. 31, 2019, as Appl. No. 16/263,098.
Application 16/263,098 is a continuation of application No. PCT/US2017/045022, filed on Aug. 2, 2017.
Claims priority of provisional application 62/473,699, filed on Mar. 20, 2017.
Claims priority of provisional application 62/460,652, filed on Feb. 17, 2017.
Claims priority of provisional application 62/370,211, filed on Aug. 2, 2016.
Prior Publication US 2019/0216910 A1, Jul. 18, 2019
Int. Cl. A61K 39/39 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 39/00 (2006.01); A61K 47/02 (2006.01); A61K 47/34 (2017.01); A61P 35/00 (2006.01)

CPC A61K 39/39 (2013.01) [A61K 9/0019 (2013.01); A61K 9/5031 (2013.01); A61K 39/0011 (2013.01); A61K 39/001106 (2018.08); A61K 39/00119 (2018.08); A61K 47/02 (2013.01); A61K 47/34 (2013.01); A61P 35/00 (2018.01); A61K 2039/5154 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55522 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/572 (2013.01); A61K 2039/6056 (2013.01); A61K 2039/812 (2018.08); A61K 2039/876 (2018.08)]

10 Claims

1. A device comprising:

a polymeric scaffold composition comprising mesoporous silica rods surface modified with a coating of polyethylenimine (PEI); and

a tumor antigen attached to the PEI,

wherein (i) the PEI does not interact with the tumor antigen to form a nanoparticle, and (ii) the PEI is not attached to CpG-ODN, poly(I:C), or poly(A:U), and

wherein the polymeric scaffold composition comprises open interconnected macropores having diameters of about 10 μm to about 600 μm.