US 12,274,739 B2
Pharmaceutical liquid composition of botulinum toxin with improved stability
Hyun Ho Jung, Seoul (KR); Gi Hyeok Yang, Chungcheongnam-do (KR); Hack Woo Kim, Chungcheongnam-do (KR); Hee Dong Woo, Chungcheongnam-do (KR); and Chang Hoon Rhee, Seoul (KR)
Assigned to MEDY-TOX, INC., Chungcheongbuk-do (KR)
Filed by Medy-Tox, Inc., Chungcheongbuk-do (KR)
Filed on May 21, 2021, as Appl. No. 17/326,797.
Application 16/416,758 is a division of application No. 14/980,285, filed on Dec. 28, 2015, granted, now 10,293,034.
Application 14/980,285 is a division of application No. 14/088,821, filed on Nov. 25, 2013, granted, now 9,220,780.
Application 17/326,797 is a continuation of application No. 17/062,007, filed on Oct. 2, 2020, abandoned.
Application 17/062,007 is a continuation of application No. 16/416,758, filed on May 20, 2019, abandoned.
Application 14/088,821 is a continuation of application No. 12/666,592, granted, now 8,617,568, previously published as PCT/KR2008/002975, filed on May 28, 2008.
Claims priority of application No. 10-2007-0069363 (KR), filed on Jul. 10, 2007.
Prior Publication US 2021/0379165 A1, Dec. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/48 (2006.01); A61K 8/44 (2006.01); A61K 8/46 (2006.01); A61K 8/49 (2006.01); A61K 8/64 (2006.01); A61K 8/66 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); A61K 47/64 (2017.01); A61Q 15/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 38/4893 (2013.01) [A61K 8/447 (2013.01); A61K 8/46 (2013.01); A61K 8/4993 (2013.01); A61K 8/64 (2013.01); A61K 8/66 (2013.01); A61K 9/0019 (2013.01); A61K 47/183 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/64 (2017.08); A61Q 15/00 (2013.01); A61Q 19/08 (2013.01); A61K 2800/52 (2013.01)] 20 Claims
 
1. A liquid pharmaceutical composition comprising botulinum toxin, polysorbate, and methionine, wherein the polysorbate ranges in concentration from 0.01 to 50 mg/mL, wherein the composition is free of gelatin or human serum albumin (HSA).