US 12,274,726 B2
Enteric aerobization therapy
Larry D. Sutton, Platte City, MO (US)
Assigned to LPOXY THERAPEUTICS, INC., Platte City, MO (US)
Filed by LPOXY THERAPEUTICS, INC., Platte City, MO (US)
Filed on Aug. 30, 2024, as Appl. No. 18/821,883.
Application 18/821,883 is a continuation of application No. 18/109,785, filed on Feb. 14, 2023, granted, now 12,109,244.
Application 18/109,785 is a continuation of application No. PCT/US2022/077091, filed on Sep. 27, 2022.
Claims priority of provisional application 63/261,828, filed on Sep. 29, 2021.
Prior Publication US 2024/0415908 A1, Dec. 19, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 36/064 (2006.01); A61K 9/28 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 31/327 (2006.01); A61K 35/742 (2015.01); A61K 35/748 (2015.01); A61K 38/44 (2006.01); A61P 31/04 (2006.01)
CPC A61K 36/064 (2013.01) [A61K 9/28 (2013.01); A61K 9/4825 (2013.01); A61K 9/5042 (2013.01); A61K 31/327 (2013.01); A61K 35/742 (2013.01); A61K 35/748 (2013.01); A61K 38/44 (2013.01); A61P 31/04 (2018.01)] 20 Claims
 
1. A method of oxygenating a region of an intestine for prevention and/or treatment of an inflammatory bowel disorder (IBD) or an intestinal anaerobic bacterial infection, the method comprising:
orally administering to a subject an oral formulation, the oral formulation comprising:
an insoluble, semipermeable external coating having a lumen;
a prodrug comprising sodium percarbonate or carbamide peroxide positioned within the lumen;
a first soluble coating surrounding the prodrug;
a catalyst comprising catalase positioned within the lumen and surrounding the prodrug coated with the first soluble coating;
a second soluble coating surrounding the catalyst;
wherein, when orally administered to a subject, water from intestinal region diffuses through the insoluble, semipermeable external coating and dissolves the first and second soluble coatings, thereby allowing the catalyst to contact the prodrug and act on the prodrug to produce oxygen, thereby oxygenating the intestinal region.