	US 12,274,712 B2
	Copper-silver-phosphate nanoparticle manufacturing method
Muhammad Nawaz, Dammam (SA); and Firdos Alam Khan, Dammam (SA)
Assigned to Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed by Imam Abdulrahman Bin Faisal University, Dammam (SA)
Filed on Jun. 29, 2023, as Appl. No. 18/343,803.
Application 18/343,803 is a division of application No. 17/579,087, filed on Jan. 19, 2022, granted, now 11,980,638.
Prior Publication US 2023/0355666 A1, Nov. 9, 2023
Int. Cl. A61K 9/14 (2006.01); A61K 33/34 (2006.01); A61K 33/38 (2006.01); A61P 35/00 (2006.01); C01B 25/45 (2006.01); C01G 3/02 (2006.01)

CPC A61K 33/38 (2013.01) [A61K 9/14 (2013.01); A61P 35/00 (2018.01); C01B 25/45 (2013.01); C01G 3/02 (2013.01); C01P 2002/72 (2013.01); C01P 2002/82 (2013.01); C01P 2002/84 (2013.01); C01P 2002/85 (2013.01); C01P 2004/03 (2013.01); C01P 2004/32 (2013.01); C01P 2006/12 (2013.01); C01P 2006/14 (2013.01); C01P 2006/16 (2013.01)]

10 Claims

1. A method of making Cu—Ag₃PO₄nanoparticles, comprising:

first forming CuO by:

dissolving copper nitrate trihydrate in water in a polytetrafluoroethylene (PTFE) lined autoclave to form a dissolved copper nitrate trihydrate;

mixing trisodium citrate and ammonium fluoride into the dissolved copper nitrate trihydrate at a temperature less than 23° C. to form a solution;

heating the solution in the PTFE lined autoclave at a temperature over 120° C. for more than 10 hours;

centrifuging the heated solution and removing excess liquid from a CuO precipitate:

washing the CuO precipitate with ethanol and water;

drying the washed CuO precipitate at a temperature less than 150° C.; and

calcining the dried CuO precipitate at a temperature greater than 300° C. to form the CuO; then

forming a mixture of at least one silver salt, at least one phosphate salt, and the CuO;

dissolving the mixture in water;

sonicating the mixture; and

precipitating the Cu—Ag₃PO₄nanoparticles;

wherein copper is present in the Cu—Ag₃PO₄nanoparticles in an amount of 2 to 23 weight percent (wt. %) based on the total weight of the Cu—Ag₃PO₄nanoparticles.