US 12,274,710 B2
Compound for regulating body weight imbalance, composition thereof and application thereof
Tianyu Sun, Guangzhou (CN); Mingjie Sun, Guangzhou (CN); Guixing Deng, Guangzhou (CN); and Changqing Li, Guangzhou (CN)
Assigned to GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD, Guangzhou (CN); GUANGZHOU XIN-CHUANGYI BIOPHARMACEUTICAL CO., LTD, Guangzhou (CN); XIANGBEI WELMAN PHARMACEUTICAL CO., LTD, Hunan (CN); and GUANGZHOU WELMAN NEW DRUG R & DCO., LTD., Guangzhou (CN)
Appl. No. 17/608,203
Filed by GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD, Guangzhou (CN); GUANGZHOU XIN-CHUANGYI BIOPHARMACEUTICAL CO., LTD, Guangzhou (CN); XIANGBEI WELMAN PHARMACEUTICAL CO., LTD, Hunan (CN); GUANGZHOU WELMAN NEW DRUG R&D CO., LTD., Guangzhou (CN); and NANJING KANGFUSHUN PHARMACEUTICAL CO., LTD, Jiangsu (CN)
PCT Filed Apr. 24, 2020, PCT No. PCT/CN2020/086698
§ 371(c)(1), (2) Date Nov. 2, 2021,
PCT Pub. No. WO2020/224452, PCT Pub. Date Nov. 12, 2020.
Claims priority of application No. 201910365916.X (CN), filed on May 5, 2019.
Prior Publication US 2022/0193104 A1, Jun. 23, 2022
Int. Cl. A61K 31/7048 (2006.01); A61P 3/04 (2006.01)
CPC A61K 31/7048 (2013.01) [A61P 3/04 (2018.01)] 15 Claims
 
1. A method for weight loss, comprising administering a therapeutically effective amount of a compound to a subject in need thereof, wherein the compound is at least one selected from the group consisting of a hydrogen sulfate having a general structure of formula (I), a metal salt of the hydrogen sulfate having the general structure of formula (I), and a metal complex of the hydrogen sulfate having the general structure of formula (I):

OG Complex Work Unit Chemistry
in formula (I),
each R is independently selected from H or —SO3H, R1 is selected from H or —SO3H, and R and R1 are not both H.