	US 12,274,709 B2
	Dual-drug co-delivery system, preparation method therefor and use thereof
Haiyan Xu, Beijing (CN); Doudou Yan, Beijing (CN); Jie Meng, Beijing (CN); Jian Liu, Beijing (CN); Tao Wen, Beijing (CN); and Yangyang Ge, Beijing (CN)
Assigned to INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES, Beijing (CN)
Appl. No. 17/433,716
Filed by Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing (CN)
PCT Filed Feb. 27, 2020, PCT No. PCT/CN2020/076891 § 371(c)(1), (2) Date Aug. 25, 2021, PCT Pub. No. WO2020/173475, PCT Pub. Date Sep. 3, 2020.
Claims priority of application No. 201910146784.1 (CN), filed on Feb. 27, 2019.
Prior Publication US 2022/0047613 A1, Feb. 17, 2022
Int. Cl. A61K 31/704 (2006.01); A61K 9/08 (2006.01); A61K 9/107 (2006.01); A61K 31/55 (2006.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); A61P 35/02 (2006.01)

CPC A61K 31/704 (2013.01) [A61K 9/08 (2013.01); A61K 9/1075 (2013.01); A61K 31/55 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61P 35/02 (2018.01)]

16 Claims

1. A dual-drug co-delivery system prepared from raw materials including a block copolymer, Homoharringtonine and Doxorubicin hydrochloride, wherein the block copolymer is selected from one or more of polyethylene caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus), methoxy polyethylene glycol-polycaprolactone (mPEG-PCL), distearoyl phosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG₂₀₀₀), polyoxyethylene polyoxypropylene ether block copolymer, polylactic acid-hydroxyacetic acid copolymer (PLGA), wherein in the dual-drug co-delivery system, the block copolymer serves as a carrier and forms a micelle with a hydrophilic shell-hydrophobic core structure, and the Homoharringtonine and Doxorubicin hydrochloride are encapsulated in the hydrophobic core of the micelle.