US 12,274,704 B2
9,11-secosteroids and the use of 9,11-secosteroids in preparing pharmaceutical compositions for inhibiting inflammation
Tsong-Long Hwang, Taoyuan (TW); Yu-Chia Chang, Taoyuan (TW); and Kuei-Hung Lai, Taoyuan (TW)
Assigned to Chang Gung University of Science and Technology, Taoyuan (TW)
Filed by Chang Gung University of Science and Technology, Taoyuan (TW)
Filed on Apr. 28, 2021, as Appl. No. 17/242,317.
Claims priority of application No. 109126808 (TW), filed on Aug. 7, 2020.
Prior Publication US 2022/0040199 A1, Feb. 10, 2022
Int. Cl. A61K 31/56 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/56 (2013.01) [A61P 29/00 (2018.01)] 6 Claims
 
1. A method for inhibiting inflammation, comprising: administering a pharmaceutical in a subject suffering from inflammation, wherein the pharmaceutical composition comprises an effective amount of 9,11-secosteroids; wherein the 9,11-secosteroids having a chemical formula (I)

OG Complex Work Unit Chemistry
while R1 is α-H, R2 is

OG Complex Work Unit Chemistry
and
while R1 is β-H, R2 is selected from

OG Complex Work Unit Chemistry
wherein the inflammation is caused by a bacterial peptide comprising N-formylmethionyl-leucyl-phenylalanine (fMLF).