US 12,274,691 B2
Envenomation therapies and related pharmaceutical compositions, systems and kits
Matthew R. Lewin, Corte Madera, CA (US)
Assigned to OPHIREX, INC, Corte Madera, CA (US)
Filed by OPHERIX, INC, Corte Madera, CA (US)
Filed on Mar. 29, 2021, as Appl. No. 17/215,466.
Application 17/215,466 is a division of application No. 15/528,418, granted, now 11,000,506, previously published as PCT/US2015/061834, filed on Nov. 20, 2015.
Claims priority of provisional application 62/082,895, filed on Nov. 21, 2014.
Claims priority of provisional application 62/243,374, filed on Oct. 19, 2015.
Claims priority of provisional application 62/131,441, filed on Mar. 11, 2015.
Prior Publication US 2021/0260029 A1, Aug. 26, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/404 (2006.01); A61K 9/00 (2006.01); A61K 31/16 (2006.01); A61K 31/167 (2006.01); A61K 31/24 (2006.01); A61K 31/245 (2006.01); A61K 31/381 (2006.01); A61K 31/405 (2006.01); A61K 31/445 (2006.01); A61K 31/541 (2006.01); A61K 38/57 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/18 (2006.01)
CPC A61K 31/404 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 31/16 (2013.01); A61K 31/167 (2013.01); A61K 31/24 (2013.01); A61K 31/245 (2013.01); A61K 31/381 (2013.01); A61K 31/405 (2013.01); A61K 31/445 (2013.01); A61K 31/541 (2013.01); A61K 38/57 (2013.01); A61K 39/39533 (2013.01); A61K 45/06 (2013.01); C07K 16/18 (2013.01); C07K 2317/55 (2013.01); Y02A 50/30 (2018.01)] 5 Claims
 
1. A method of treating a patient or subject suffering from envenomation by a snake comprising administering to said patient or subject, a therapeutically effective amount of a PLA2 inhibitor selected from the group consisting of varespladib, methylvarespladib, a pharmaceutically acceptable salt thereof, or a combination thereof, in combination with a pharmaceutically acceptable carrier, additive or excipient and at least one additional agent selected from the group consisting of a metalloproteinase inhibitor, a snake antivenom or a mixture thereof.