US 12,274,686 B2
Specialized pro-resolving mediators (SPMs) as melanocyte growth promoter and pro-survival factors and uses thereof
Youwen Zhou, Vancouver (CA)
Assigned to The University of British Columbia, Vancouver (CA)
Appl. No. 18/026,765
Filed by THE UNIVERSITY OF BRITISH COLUMBIA, Vancouver (CA)
PCT Filed Mar. 18, 2022, PCT No. PCT/CA2022/050415
§ 371(c)(1), (2) Date Mar. 16, 2023,
PCT Pub. No. WO2022/193029, PCT Pub. Date Sep. 22, 2022.
Claims priority of provisional application 63/163,241, filed on Mar. 19, 2021.
Prior Publication US 2023/0285344 A1, Sep. 14, 2023
Int. Cl. A61K 31/202 (2006.01); A61K 9/00 (2006.01); A61P 17/00 (2006.01)
CPC A61K 31/202 (2013.01) [A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61P 17/00 (2018.01)] 13 Claims
OG exemplary drawing
 
1. A method of promoting melanocyte growth and/or survival in a subject having age-associated leukoderma, age-associated leukotrichia, dormant vitiligo lesions, chemically induced vitiligo, vitiligo that is non-responsive to inflammatory therapies, or canities, the method comprising administering to the subject one or more specialized pro-resolving mediators (SPMs) or a pharmaceutically acceptable salt, hydrate, or hydrated salt, or its optical isomer, racemate, diastereoisomer or enantiomer thereof, excluding lipoxin A4.