US 12,274,685 B2
Compositions comprising 15-HEPE and methods of using the same
David Coughlan, Dublin (IE); and John Climax, Dublin (IE)
Assigned to Afimmune Limited, (IE)
Filed by Afimmune Limited, Dublin (IE)
Filed on May 20, 2022, as Appl. No. 17/750,262.
Application 17/750,262 is a continuation of application No. 17/502,462, filed on Oct. 15, 2021, abandoned.
Application 17/502,462 is a continuation of application No. 17/174,022, filed on Feb. 11, 2021, abandoned.
Application 17/174,022 is a continuation of application No. 16/921,221, filed on Jul. 6, 2020, abandoned.
Application 16/921,221 is a continuation of application No. 16/263,486, filed on Jan. 31, 2019, abandoned.
Application 16/263,486 is a continuation of application No. 15/841,363, filed on Dec. 14, 2017, granted, now 10,231,945, issued on Mar. 19, 2019.
Application 15/841,363 is a continuation of application No. 15/383,889, filed on Dec. 19, 2016, granted, now 9,855,238, issued on Jan. 2, 2018.
Claims priority of provisional application 62/269,280, filed on Dec. 18, 2015.
Prior Publication US 2023/0106655 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/202 (2006.01); A61K 31/232 (2006.01)
CPC A61K 31/202 (2013.01) [A61K 31/232 (2013.01)] 18 Claims
 
1. A method of increasing absorption of 15-hydroxyeicosapentaenoic acid (15-HEPE) in a subject in need thereof, comprising administering a pharmaceutical composition comprising 15-HEPE in free acid form or a pharmaceutically acceptable ester, conjugate, or salt thereof to the subject, wherein the subject is in a fed state having had a meal within the preceding 4 hours.