US 12,274,682 B2
Compositions and methods for controlling food intake of animal
Kee-Hong Kim, West Lafayette, IN (US); and Yuyan Zhu, Shenzhen (CN)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on Oct. 15, 2022, as Appl. No. 18/046,917.
Application 18/046,917 is a continuation of application No. 17/343,589, filed on Jun. 9, 2021, granted, now 11,872,198.
Application 17/343,589 is a continuation of application No. 16/461,597, granted, now 11,065,216, issued on Jul. 20, 2021, previously published as PCT/US2017/061893, filed on Nov. 16, 2017.
Claims priority of provisional application 62/422,722, filed on Nov. 16, 2016.
Prior Publication US 2023/0285333 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/18 (2006.01); A61K 31/167 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); C12N 15/113 (2010.01)
CPC A61K 31/18 (2013.01) [A61K 31/167 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); C12N 15/1137 (2013.01); A61P 3/06 (2018.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of regulating food intake in a companion animal, the method comprising parenterally administering at least once per month to a companion animal a therapeutically effective amount of a composition comprising, as an active agent, avasimibe or a pharmacologically acceptable salt thereof that non-selectively inhibits in vivo both acyl-coenzyme A, cholesterol acyltransferase 1 (ACAT1) and acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2),
wherein the degree that the active agent inhibits ACAT1 is less than 1 degree that the active agent inhibits ACAT2, and
wherein the active agent reduces food intake in the companion animal.