| CPC A61B 5/1495 (2013.01) [A61B 5/14532 (2013.01); A61B 5/7221 (2013.01)] | 22 Claims |

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1. A continuous glucose monitoring system, comprising:
a glucose sensor having a first portion configured to be positioned through a user's skin and in contact with an interstitial fluid of the user for in vivo detection of glucose and a second portion configured to remain above the user's skin;
a non-transitory memory; and
at least one processor communicatively coupled to the non-transitory memory and the glucose sensor and configured to:
receive a current blood glucose measurement of the user determined based on a finger prick test using a lancing device in conjunction with a blood glucose meter;
provide a prompt to accept or decline execution of a calibration routine using the current blood glucose measurement;
upon receiving an acceptance to the prompt to accept or decline execution of a calibration routine using the current blood glucose measurement, confirm:
(1) that the current blood glucose measurement is within a glucose-value range, and
(2) that a rate of change of a glucose level detected by the glucose sensor is within a rate-of-change range;
upon confirming (1) and (2) initiate the calibration routine and calibrate the glucose sensor using the current blood glucose measurement;
wherein if a declination to the prompt to accept or decline execution of a calibration routine using the current blood glucose measurement is received, the at least one processor is further configured to store the current blood glucose measurement.
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