US 12,274,547 B2
Optical determination of a cardiovascular variability parameter independent of skin contributions
Kimani Toussaint, Providence, RI (US); Rutendo Jakachira, Providence, RI (US); Mbaye Diouf, Providence, RI (US); Joshua Burrow, Providence, RI (US); and Zixi Lin, Providence, RI (US)
Assigned to BROWN UNIVERSITY, Providence, RI (US)
Appl. No. 18/681,759
Filed by BROWN UNIVERSITY, Providence, RI (US)
PCT Filed Aug. 11, 2022, PCT No. PCT/US2022/040020
§ 371(c)(1), (2) Date Feb. 6, 2024,
PCT Pub. No. WO2023/018846, PCT Pub. Date Feb. 16, 2023.
Claims priority of provisional application 63/231,973, filed on Aug. 11, 2021.
Claims priority of provisional application 63/353,566, filed on Jun. 18, 2022.
Prior Publication US 2025/0000398 A1, Jan. 2, 2025
Int. Cl. A61B 5/1455 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/024 (2006.01); A61B 5/026 (2006.01); A61B 5/08 (2006.01)
CPC A61B 5/14552 (2013.01) [A61B 5/14558 (2013.01); A61B 5/7275 (2013.01); A61B 5/02007 (2013.01); A61B 5/02028 (2013.01); A61B 5/021 (2013.01); A61B 5/02444 (2013.01); A61B 5/0261 (2013.01); A61B 5/0803 (2013.01); A61B 5/0816 (2013.01); A61B 2560/0443 (2013.01); A61B 2560/0462 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
a light source configured to generate a light to illuminate a biological tissue of a patient;
a polarization shaping device configured to polarize the light to have an inhomogeneous optical polarization wavefront creating polarized light, wherein the polarized light is configured to interact with the biological tissue of the patient, wherein the interaction is reflectance and/or transmission;
a polarization analyzer configured to:
receive interacted polarized light comprising the polarized light reflected after the polarized light interacts the biological tissue of the patient; and
output at least a first polarization state and a second polarization state of the interacted polarized light,
wherein a portion of the polarization analyzer is oriented at a first angle relative to the interacted polarized light to output the first polarization state and another portion of the polarization analyzer is oriented at a second angle relative to the interacted polarized light to output the second polarization state; and
a detection device comprising:
a light detector configured to detect the first and second polarization states of the interacted polarized light output by the polarization analyzer, and
at least a processor configured to execute instructions to:
detect data related to the first polarization state of the interacted polarized light and data related to the second polarization state of the interacted polarized light;
determine relative absorption contributions of a superficial component and a deep component of the biological tissue of the patient based on the data related to the first polarization state of the interacted polarized light and the data related to the second polarization state of the interacted polarized light; and
determine a cardiovascular variability parameter of the patient based on the relative absorption contributions of the superficial component and the deep component, wherein the determination is independent of an absorption effect of melanin in the biological tissue.