| CPC A61B 17/22 (2013.01) [A61B 2017/00867 (2013.01); A61B 2017/22038 (2013.01); A61B 2017/22079 (2013.01)] | 29 Claims |

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1. A method of treating a pulmonary embolism within the vasculature of a patient, the method comprising:
advancing an aspiration catheter at least partially through the vasculature of the patient such that a distal portion of the aspiration catheter is positioned proximate to the pulmonary embolism, wherein the aspiration catheter defines an aspiration lumen;
generating vacuum pressure within a barrel of a syringe;
storing the vacuum pressure within the barrel;
applying the vacuum pressure to the aspiration lumen to aspirate at least a first portion of the pulmonary embolism into the aspiration lumen by moving a valve from a first position to a second position to permit fluid flow from the aspiration lumen to the barrel;
determining that a second portion of the pulmonary embolism remains within the vasculature;
advancing a clot treatment device having an expandable member through the aspiration lumen such that the clot treatment device is positioned at least partially distal to the second portion of the pulmonary embolism;
expanding the expandable member of the clot treatment device within the vasculature distal of the pulmonary embolism such that the expandable member has a proximal tapered region and a distal tapered region, wherein the expandable member includes a plurality of interconnected struts forming a unitary structure; and
proximally retracting the expandable member through the second portion of the pulmonary embolism to capture and/or disrupt the second portion of the pulmonary embolism.
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