US 12,274,450 B2
Devices and methods for trans-arterial osmotic embolization of pathological tissue
John Pile-Spellman, Pelham, NY (US); and Jae H. Choi, Mineola, NY (US)
Assigned to Transluminal Systems, LLC, New Rochelle, NY (US)
Filed by Transluminal Systems, LLC, New Rochelle, NY (US)
Filed on Aug. 2, 2021, as Appl. No. 17/391,136.
Claims priority of provisional application 63/060,197, filed on Aug. 3, 2020.
Prior Publication US 2022/0031336 A1, Feb. 3, 2022
Int. Cl. A61B 17/12 (2006.01); A61B 6/00 (2024.01); A61B 6/50 (2024.01); A61M 5/00 (2006.01); A61B 17/00 (2006.01)
CPC A61B 17/12186 (2013.01) [A61B 6/504 (2013.01); A61M 5/007 (2013.01); A61B 2017/00022 (2013.01); A61B 2017/1205 (2013.01); A61M 2205/3327 (2013.01); A61M 2205/3334 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An endovascular interventional method comprising:
inserting a catheter into a target blood vessel, wherein the catheter is coupled to a controller and one or more sensors, the controller and the one more sensors providing a continuous delivery of contrast and of a hyperosmotic fluid supply;
injecting the contrast and determining a rate of flow that achieves angiographic filling of the target blood vessel at a first time;
injecting the hyperosmotic fluid continuously at the rate of flow that achieves angiographic filling at the first time for a first period of time;
injecting the contrast and determining a rate of flow that achieves angiographic filling of the target blood vessel at a second time following the first period of time;
injecting the hyperosmotic fluid continuously at the rate of flow that achieves angiographic filling at the second time for a second period of time;
injecting the contrast and determining a rate of flow that achieves complete opacification of the target blood vessel; and
injecting the hyperosmotic fluid continuously until dehydration of the target blood vessel occurs.