	US 11,952,577 B2
	Yarrowia lipolytica yeast strains expressing an HMG-CoA reductase having increased activity or expression
Keith A. Walker, San Diego, CA (US); Mark E. Knuth, Poway, CA (US); Noel M. Fong, San Diego, CA (US); and Peter R. Beetham, Carlsbad, CA (US)
Assigned to NUCELIS LLC, San Diego, CA (US)
Filed by NUCELIS LLC, San Diego, CA (US)
Filed on Jan. 9, 2017, as Appl. No. 15/401,776.
Application 15/401,776 is a continuation of application No. 13/926,288, filed on Jun. 25, 2013, granted, now 9,540,662.
Application 13/926,288 is a continuation of application No. 12/952,161, filed on Nov. 22, 2010, granted, now 8,470,568, issued on Jun. 25, 2013.
Claims priority of provisional application 61/263,775, filed on Nov. 23, 2009.
Prior Publication US 2017/0145429 A1, May 25, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/81 (2006.01); C12N 1/16 (2006.01); C12N 15/52 (2006.01); C12P 5/00 (2006.01); C12P 5/02 (2006.01); C12R 1/73 (2006.01)

CPC C12N 15/815 (2013.01) [C12N 1/165 (2021.05); C12N 15/52 (2013.01); C12P 5/007 (2013.01); C12P 5/026 (2013.01); C12R 2001/73 (2021.05)]

1 Claim

1. A composition comprising:

a yeast Yarrowia lipolytica strain selected from the group consisting of ATCC 20688, A TCC 90811, A TCC 90904, ATCC 90812, ATCC MYA-2613, or Yeastern polg that is genetically modified to overexpress the 457 amino-acid C-terminal catalytic domain of the hydroxymethylglutaryl CoA reductase from Yarrowia lipolytica encoded by the HMG1 gene.