US 11,952,469 B2
Hydrogel composition with thermos-sensitive and ionic reversible properties, carrier, method for preparing and method of use thereof
Hsieh-Chih Tsai, New Taipei (TW); Shuian-Yin Lin, Hsinchu County (TW); and Hsiao-Ying Chou, New Taipei (TW)
Assigned to National Taiwan University of Science and Technology, Taipei (TW)
Filed by National Taiwan University of Science and Technology, Taipei (TW)
Filed on Apr. 1, 2021, as Appl. No. 17/219,915.
Claims priority of application No. 109138731 (TW), filed on Nov. 5, 2020.
Prior Publication US 2022/0135748 A1, May 5, 2022
Int. Cl. C08J 3/075 (2006.01); A61L 26/00 (2006.01); C08J 3/24 (2006.01)
CPC C08J 3/075 (2013.01) [A61L 26/0052 (2013.01); A61L 26/008 (2013.01); C08J 3/24 (2013.01); C08J 2305/04 (2013.01); C08J 2333/26 (2013.01); C08J 2371/02 (2013.01)] 19 Claims
 
1. A method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties, comprising following steps:
providing a thermos-sensitive polymer;
providing an anionic polymer comprising polysaccharide having at least one carboxylic acid;
dissolving and mixing the thermos-sensitive polymer and the anionic polymer in a solvent to obtain an initial solution; and
performing a mixing process with the initial solution and an anionic crosslinking agent, wherein when the initial solution and the anionic crosslinking agent are in contact at a temperature over a lower critical solution temperature (LCST), crosslinking occurs to obtain the hydrogel composition with thermos-sensitive and ionic reversible properties, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has ordered structure in a gel state, and the hydrogel composition with thermos-sensitive and ionic reversible properties can reversibly transfer from the gel state to a solution state,
wherein a weight ratio of the thermos-sensitive polymer and the anionic polymer is 1:0.02-0.12,
wherein when the hydrogel composition contacts a metal chelate aqueous solution having a temperature lower than the LCST of the hydrogel composition, the hydrogel composition transfers from a gel state to a solution state.