US 11,952,435 B2
Highly crystalline alpha-1,3-glucan
Kyle Hyun Chang Kim, Wilmington, DE (US); Yefim Brun, Wilmington, DE (US); Lucia Daniela Ionescu, Oegstgeest (NL); Juan David Londono, Bear, DE (US); Jorge Mok, Wilmington, DE (US); James Joshua Ohane, West Chester, PA (US); and Lemuel Tong, Kingston (CA)
Assigned to NUTRITION & BIOSCIENCES USA 4, INC., Rochester, NY (US)
Filed by NUTRITION & BIOSCIENCES USA 4, INC., Rochester, NY (US)
Filed on Mar. 16, 2023, as Appl. No. 18/184,845.
Application 18/184,845 is a continuation of application No. 17/089,817, filed on Nov. 5, 2020, granted, now 11,608,388.
Claims priority of provisional application 63/084,036, filed on Sep. 28, 2020.
Claims priority of provisional application 63/035,978, filed on Jun. 8, 2020.
Claims priority of provisional application 62/931,242, filed on Nov. 6, 2019.
Claims priority of provisional application 62/931,239, filed on Nov. 6, 2019.
Prior Publication US 2023/0383014 A1, Nov. 30, 2023
Int. Cl. C08B 37/00 (2006.01); A23B 7/154 (2006.01); A23B 7/16 (2006.01); A23L 3/349 (2006.01); A61K 8/73 (2006.01); A61K 47/36 (2006.01); A61Q 17/04 (2006.01); C08L 7/00 (2006.01); C08L 75/04 (2006.01); C09D 7/65 (2018.01); C09D 175/04 (2006.01); D21H 17/24 (2006.01); D21H 19/12 (2006.01)
CPC C08B 37/0009 (2013.01) [A23B 7/154 (2013.01); A23B 7/16 (2013.01); A23L 3/349 (2013.01); A61K 8/73 (2013.01); A61K 47/36 (2013.01); A61Q 17/04 (2013.01); C08L 7/00 (2013.01); C08L 75/04 (2013.01); C09D 7/65 (2018.01); C09D 175/04 (2013.01); D21H 17/24 (2013.01); D21H 19/12 (2013.01); A23V 2002/00 (2013.01); A61K 2800/10 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of producing insoluble alpha-glucan particles, said method comprising:
(a) providing insoluble alpha-glucan as produced in an enzymatic reaction comprising at least water, sucrose and a glucosyltransferase enzyme that synthesizes the insoluble alpha-glucan, wherein the insoluble alpha-glucan has a weight-average degree of polymerization (DPw) of at least about 200 and at least 50% of the glycosidic linkages of the insoluble alpha-glucan are alpha-1,3 glycosidic linkages; and
(b) hydrolyzing the insoluble alpha-glucan to insoluble alpha-glucan particles, wherein said hydrolyzing is performed under aqueous conditions at a pH of 2.0 or less;
wherein the insoluble alpha-glucan particles produced in step (b) have a degree of crystallinity of at least about 0.65 and a DPw of at least 15, and at least 50% of the glycosidic linkages of the insoluble alpha-glucan particles are alpha-1,3 glycosidic linkages.