US 11,952,424 B2
Multivalent antibody
Cornelis Adriaan de Kruif, Utrecht (NL); Linda Johanna Aleida Hendriks, Utrecht (NL); and Ton Logtenberg, Utrecht (NL)
Assigned to merus n.v., Utrecht (NL)
Filed by MERUS N.V., Utrecht (NL)
Filed on Mar. 29, 2019, as Appl. No. 16/370,346.
Claims priority of provisional application 62/650,467, filed on Mar. 30, 2018.
Prior Publication US 2019/0352401 A1, Nov. 21, 2019
Int. Cl. C07K 16/28 (2006.01)
CPC C07K 16/2827 (2013.01) [C07K 16/2809 (2013.01); C07K 16/2851 (2013.01); C07K 16/2863 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/522 (2013.01); C07K 2317/53 (2013.01); C07K 2317/55 (2013.01)] 47 Claims
 
1. A multivalent antibody which comprises:
a base antibody portion which comprises two binding domains; and
one or two additional binding domains,
wherein the base antibody portion is a full length immunoglobulin,
wherein the one or two additional binding domains are Fab domains comprising a CH1 region, each Fab domain being connected to the base antibody portion by a linker, linking a variable region of the base antibody portion and the CH1 region,
wherein each binding domain of the base antibody portion and each of the one or two additional binding domains all have the same light chain, the light chain comprising the complementarity determining regions (CDRs) of IGKV1-39/jk1 or IGKV1-39/jk5, and
wherein the multivalent antibody binds to at least three different epitopes or antigens.