US 11,952,402 B2
Fusion protein containing trail and IgG binding domain and the uses thereof
Xiaofeng Lu, Sichuan (CN); Hao Yang, Sichuan (CN); Ze Tao, Sichuan (CN); and Jingqiu Cheng, Sichuan (CN)
Assigned to WEST CHINA HOSPITAL, SICHUAN UNIVERSITY, Sichuan (CN)
Filed by WEST CHINA HOSPITAL, SICHUAN UNIVERSITY, Sichuan (CN)
Filed on Aug. 10, 2020, as Appl. No. 16/989,654.
Application 16/989,654 is a continuation in part of application No. PCT/CN2019/073994, filed on Jan. 30, 2019.
Claims priority of application No. 201810128333.0 (CN), filed on Feb. 8, 2018.
Prior Publication US 2021/0101944 A1, Apr. 8, 2021
Int. Cl. C07K 14/315 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01)
CPC C07K 14/315 (2013.01) [A61K 38/164 (2013.01); A61K 38/177 (2013.01); A61P 35/00 (2018.01); C07K 14/70575 (2013.01); C07K 16/2803 (2013.01); C07K 16/2863 (2013.01); C07K 2319/00 (2013.01)] 15 Claims
 
1. A nucleotide sequence, comprising:
(1) a sequence segment encoding a function domain of TRAIL; and
(2) a sequence segment encoding a IgG-binding domain;
wherein the TRAIL is derived from monkey or human TRAIL the IgG-binding domain is from streptococcus protein G, and
wherein the nucleotide sequence is shown as any one of SEQ ID NO:7, 8 or 15.