	US 11,952,351 B2
	Lipid particle, composition comprising lipid particle, and method for delivering activators to cell
Mitsuko Ishihara, Setagaya (JP); Eiichi Akahoshi, Shinagawa (JP); Katsuyuki Naito, Bunkyo (JP); Emi Nozaki, Shinagawa (JP); and Saeko Saruwatari, Kawasaki (JP)
Assigned to KABUSHIKI KAISHA TOSHIBA, Tokyo (JP)
Filed by KABUSHIKI KAISHA TOSHIBA, Tokyo (JP)
Filed on Nov. 29, 2022, as Appl. No. 18/059,765.
Application 18/059,765 is a continuation of application No. 16/812,625, filed on Mar. 9, 2020, granted, now 11,548,857.
Application 16/812,625 is a continuation of application No. PCT/JP2019/010681, filed on Mar. 14, 2019.
Claims priority of application No. 2018-154955 (JP), filed on Aug. 21, 2018.
Prior Publication US 2023/0099139 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 243/08 (2006.01); A61K 9/127 (2006.01); C07C 229/30 (2006.01); C07D 211/14 (2006.01); C07D 233/02 (2006.01); C07D 241/04 (2006.01); A61K 31/7088 (2006.01)

CPC C07D 243/08 (2013.01) [A61K 9/1271 (2013.01); C07C 229/30 (2013.01); C07D 211/14 (2013.01); C07D 233/02 (2013.01); C07D 241/04 (2013.01); A61K 31/7088 (2013.01)]

27 Claims

1. Lipid particles comprising a lipid compound represented by the formula (1):

Q-CHR₂ (1)

wherein

Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and

each R is independently an aliphatic group of C₁₂to C₂₄, and is represented by the following formula (1-R):

-L^R1-C(═O)—O-L^R2 (1-R)

wherein

L^R1and L^R2are alkylene and alkenyl, respectively;

wherein the lipid particles contain

25 to 75 mol % of said lipid compound represented by the formula (1); and

1 to 10 mol % of a lipid capable of reducing aggregation,

based on the total number of moles of the lipids used for the lipid particles, respectively.