US 11,951,177 B2
High sterol-containing lipid nanoparticles
Kevin An, Vancouver (CA); Daniel Kurek, Vancouver (CA); Jayesh Kulkarni, Vancouver (CA); and Dominik Witzigmann, Vancouver (CA)
Assigned to NanoVation Therapeutics Inc., Vancouver (CA)
Filed by NanoVation Therapeutics Inc., Vancouver (CA)
Filed on Mar. 22, 2023, as Appl. No. 18/187,904.
Claims priority of provisional application 63/269,815, filed on Mar. 23, 2022.
Prior Publication US 2023/0302153 A1, Sep. 28, 2023
Int. Cl. A61K 47/69 (2017.01); A61K 31/575 (2006.01); A61K 31/661 (2006.01); C12N 15/113 (2010.01)
CPC A61K 47/6909 (2017.08) [A61K 31/575 (2013.01); A61K 31/661 (2013.01); C12N 15/113 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A lipid nanoparticle comprising:
a nucleic acid cargo molecule;
a sterol or a derivative thereof present at a mol % content between 49 mol % and 85 mol %;
a phospholipid content of 4 mol % or less;
an ionizable lipid content that is less than 40 mol %; and
a hydrophilic polymer-lipid conjugate present at a content between 0.5 and 2.5 mol %,
wherein each mol % content is relative to total lipid present in the lipid nanoparticle.