US 11,951,158 B2
Compositions and methods for administering PPARγ agonists, surfactant peptides and phospholipids
Virender K. Rehan, Torrance, CA (US); John S. Torday, Torrance, CA (US); Frans J. Walther, Torrance, CA (US); Alan J. Waring, Torrance, CA (US); and Larry M. Gordon, Torrance, CA (US)
Assigned to LINDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER, Torrance, CA (US)
Filed by LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER, Torrance, CA (US)
Filed on Nov. 1, 2021, as Appl. No. 17/516,291.
Application 17/516,291 is a continuation of application No. 16/082,224, granted, now 11,179,446, previously published as PCT/US2017/020881, filed on Mar. 6, 2017.
Claims priority of provisional application 62/304,845, filed on Mar. 7, 2016.
Prior Publication US 2022/0047681 A1, Feb. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/39 (2006.01); A61K 9/00 (2006.01); A61K 31/4439 (2006.01); A61K 38/17 (2006.01); A61K 47/24 (2006.01); A61P 11/00 (2006.01)
CPC A61K 38/395 (2013.01) [A61K 9/0078 (2013.01); A61K 31/4439 (2013.01); A61K 47/24 (2013.01); A61P 11/00 (2018.01)] 11 Claims
 
1. A method of preventing or treating surfactant deficiency or dysfunction in a patient in need thereof, comprising aerosol administration of composition comprising:
a PPAR (peroxisome proliferator-activated receptor) gamma agonist;
one or more surfactant peptides; and
one or more phospholipids,
wherein the patient is an infant wherein at least one of the one or more surfactant peptides comprises:
(i) a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO: 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and
(ii) a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO: 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2,
wherein (a) X is any amino acid but at least one amino acid at the X positions is tyrosine, and (b) Z is any amino acid but not methionine.