	US 11,951,120 B2
	Modification of gene transcription and translation efficiency by 5′UTR sequence variation
Jaewoo Lee, Cary, NC (US); Dehua Wang, Nanjing (CN); Xiaoyao Hao, Nanjing (CN); Yue Gao, Nanjing (CN); Jie Liu, Nanjing (CN); Shan He, Nanjing (CN); Ting He, Lexington, MA (US); and Dan Tse, Andover, MA (US)
Assigned to Nanjing GeneLeap Biotechnology Co., Ltd.
Filed by Nanjing GeneLeap Biotechnology Co., Ltd., Nanjing (CN)
Filed on Dec. 7, 2022, as Appl. No. 18/076,638.
Claims priority of provisional application 63/287,484, filed on Dec. 8, 2021.
Prior Publication US 2023/0310484 A1, Oct. 5, 2023
Int. Cl. A61K 31/7105 (2006.01); A61K 38/00 (2006.01); C07K 14/025 (2006.01); C07K 14/54 (2006.01)

CPC A61K 31/7105 (2013.01) [C07K 14/025 (2013.01); C07K 14/5434 (2013.01); A61K 38/00 (2013.01)]

20 Claims

1. An isolated nucleic acid comprising, in the 5′ to 3′ direction:

a) at least one 5′UTR element, said 5′UTR element comprising polynucleotides comprising SEQ ID NO: 38; and

b) at least one open reading frame (ORF) encoding a peptide or protein.