	US 11,951,106 B2
	Method of increasing bioavailability and/or prolonging ophthalmic action of a drug
Ajay Jaysingh Khopade, Baroda (IN); and Arindam Halder, Baroda (IN)
Assigned to SUN PHARMA ADVANCED RESEARCH COMPANY LTD., Maharashtra (IN)
Filed by SUN PHARMA ADVANCED RESEARCH COMPANY LTD., Mumbai (IN)
Filed on Jun. 17, 2021, as Appl. No. 17/304,309.
Application 17/304,309 is a continuation of application No. 16/180,731, filed on Nov. 5, 2018, granted, now 11,058,684.
Application 16/180,731 is a continuation of application No. 15/329,824, granted, now 10,172,852, previously published as PCT/IN2015/050076, filed on Jul. 24, 2015.
Claims priority of application No. 2437/MUM/2014 (IN), filed on Jul. 28, 2014; and application No. 2206/MUM/2015 (IN), filed on Jun. 9, 2015.
Prior Publication US 2021/0308130 A1, Oct. 7, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/498 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/16 (2006.01); A61K 9/51 (2006.01); A61K 45/06 (2006.01); B01J 39/20 (2006.01)

CPC A61K 31/498 (2013.01) [A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/08 (2013.01); A61K 9/1635 (2013.01); A61K 9/5176 (2013.01); A61K 45/06 (2013.01); B01J 39/20 (2013.01)]

19 Claims

1. A method of treating glaucoma in a patient need thereof comprising administering to the patient an ophthalmic formulation comprising an aqueous suspension containing brimonidine or its pharmaceutically acceptable salt at a concentration of from about 0.05 to about 0.5% weight by volume, and a cation exchange resin, wherein the suspension is suitable for once-a-day topical instillation.