US 11,950,995 B2
Bioartificial pancreas
Sara Joan Photiadis, San Francisco, CA (US); Douglas Marc Photiadis, Alexandria, VA (US); and Thomas A. Kramer, San Carlos, CA (US)
Assigned to ISLA Technologies, Inc., San Carlos, CA (US)
Filed by ISLA Technologies, Inc., San Carlos, CA (US)
Filed on Mar. 31, 2023, as Appl. No. 18/193,959.
Application 18/193,959 is a continuation of application No. 17/981,287, filed on Nov. 4, 2022, granted, now 11,642,212.
Application 17/981,287 is a continuation of application No. 17/697,692, filed on Mar. 17, 2022, granted, now 11,517,416, issued on Dec. 6, 2022.
Application 17/697,692 is a continuation of application No. PCT/US2020/052432, filed on Sep. 24, 2020.
Claims priority of provisional application 62/907,434, filed on Sep. 27, 2019.
Prior Publication US 2023/0248505 A1, Aug. 10, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61F 2/02 (2006.01); A61F 2/07 (2013.01); A61F 2/90 (2013.01); A61K 35/39 (2015.01); A61L 27/56 (2006.01); A61L 31/00 (2006.01); A61L 31/08 (2006.01); C12N 5/071 (2010.01)
CPC A61F 2/022 (2013.01) [A61F 2/07 (2013.01); A61F 2/90 (2013.01); A61K 35/39 (2013.01); A61L 27/56 (2013.01); A61L 31/005 (2013.01); A61L 31/08 (2013.01); C12N 5/0678 (2013.01); A61F 2210/0004 (2013.01); A61F 2210/0076 (2013.01); A61F 2220/0075 (2013.01); A61F 2240/002 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/608 (2013.01); A61L 2300/64 (2013.01); A61L 2420/08 (2013.01); C12N 2513/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A bioartificial implant system, the system comprising:
a scaffold configured to engage an interior wall of a blood vessel of a subject, the scaffold comprising a lumen extending longitudinally through an interior cavity of the scaffold so as to permit blood flow therethrough when the scaffold is engaged with the blood vessel; and
a cellular complex support supported by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising
one or more pockets and a plurality of attachment regions configured to attach to the scaffold, and
at least one microporous thin film layer bordering the one or more pockets,
the cellular complex support configured to receive a plurality of cells within the one or more pockets, and wherein the cellular complex support is configured to permit nutrients to diffuse from the blood flow into the one or more pockets.