US 11,950,958 B2
Adaptive pulsing for sonothrombolysis treatment
William Tao Shi, Wakefield, MA (US); Jonathon Thomas Sutton, Boston, MA (US); Jeffry Earl Powers, Bainbridge Island, WA (US); and Ralf Seip, Cambridge, MA (US)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed on Jan. 14, 2022, as Appl. No. 17/576,389.
Application 17/576,389 is a continuation of application No. 16/469,764, granted, now 11,259,781, previously published as PCT/IB2017/057825, filed on Dec. 12, 2017.
Claims priority of provisional application 62/435,139, filed on Dec. 16, 2016.
Prior Publication US 2022/0133277 A1, May 5, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 8/00 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01); A61N 7/00 (2006.01)
CPC A61B 8/481 (2013.01) [A61B 8/06 (2013.01); A61B 8/0816 (2013.01); A61B 8/0891 (2013.01); A61N 7/00 (2013.01); A61N 2007/0039 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method comprising:
transmitting an ultrasound treatment pulse to a treatment region of a subject, the treatment region comprising a plurality of microbubbles;
receiving one or more microbubble echoes comprising a reflection of the ultrasound treatment pulse by the plurality of microbubbles, wherein the received microbubble echoes is distinct from imaging echoes for ultrasonically imaging the treatment region;
identifying, from the received microbubble echoes, at least one microbubble echo signature indicative of a dynamic state of the plurality of microbubbles in response to the ultrasound treatment pulse, wherein the at least one microbubble echo signature comprises at least one of:
a frequency of the received microbubble echoes;
an intensity of the received microbubble echoes; or
a change over time of the intensity of the received microbubble echoes; and
adjusting one or more parameters of an additional ultrasound pulse transmitted to the treatment region based on the at least one microbubble echo signature.