US 11,950,907 B2
Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflecting medium with time-varying optical properties
Kimberly Shultz, Mountain View, CA (US); Jennifer Keating, Mountain View, CA (US); Edward Solomon, Menlo Park, CA (US); and Kate Bechtel, Pleasant Hill, CA (US)
Assigned to MEDIBEACON, INC., St. Louis, MO (US)
Filed by MediBeacon Inc., St. Louis, MO (US)
Filed on Sep. 16, 2022, as Appl. No. 17/932,713.
Application 17/932,713 is a continuation of application No. 17/200,381, filed on Mar. 12, 2021, granted, now 11,478,172.
Application 17/200,381 is a continuation of application No. 16/717,436, filed on Dec. 17, 2019, granted, now 10,980,459, issued on Apr. 20, 2021.
Application 16/717,436 is a continuation of application No. 15/884,365, filed on Jan. 30, 2018, granted, now 10,548,521, issued on Feb. 4, 2020.
Claims priority of provisional application 62/452,025, filed on Jan. 30, 2017.
Prior Publication US 2023/0021174 A1, Jan. 19, 2023
Int. Cl. G06F 11/30 (2006.01); A61B 5/00 (2006.01); A61B 5/1455 (2006.01); A61B 5/20 (2006.01); G01J 1/04 (2006.01); G01J 1/44 (2006.01)
CPC A61B 5/14556 (2013.01) [A61B 5/0071 (2013.01); A61B 5/201 (2013.01); A61B 5/6832 (2013.01); A61B 5/7235 (2013.01); A61B 5/742 (2013.01); G01J 1/0407 (2013.01); G01J 1/44 (2013.01); A61B 2560/0242 (2013.01); A61B 2562/0242 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties, the method comprising:
using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement data entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent, the at least two measurements selected from:
a DRex signal detected at a second region adjacent to the diffuse reflecting medium by an unfiltered light detector during illumination of the diffuse reflecting medium by excitatory-wavelength light from a first region adjacent to the diffuse reflecting medium;
an Flr signal detected at a third region adjacent to the diffuse reflecting medium by a filtered light detector during illumination of the diffuse reflecting medium by excitatory-wavelength light from the first region;
a DRem signal detected at the second region by the unfiltered light detector during illumination of the diffuse reflecting medium by emission-wavelength light from the first region; and
a DRem,filtered signal detected at the third region by the filtered light detector during illumination of the diffuse reflecting medium by emission-wavelength light from the first region,
wherein the at least two measurements comprise the Flr signal and the DRem,filtered signal, and
wherein the at least one controller further comprises a processing unit, wherein said processing unit comprises a post-agent administration selection subunit, said post-agent administration selection subunit configured to identify a post-agent administration portion of the measurement data set and a post-equilibration portion of the measurement data set;
identifying the post-agent administration portion of the measurement data set;
transforming each Flr signal of each measurement data entry within the post-agent administration portion of the measurement data set to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the diffuse reflecting medium, wherein the transforming comprises combining the at least two measurements according to a transformation relation comprising a mathematical equation converting Flr to IF;
identifying the post-equilibration portion of the measurement data set;
transforming the IF signals corresponding to the post-equilibration portion of the measurement data set to a rate of change of the IF signals; and
determining renal function in the patient based on the rate of change of the IF signals.