| CPC A61N 1/36031 (2017.08) [A61B 5/085 (2013.01); A61B 5/087 (2013.01); A61M 16/00 (2013.01); A61N 1/3601 (2013.01); A61B 5/0803 (2013.01); A61M 2016/0021 (2013.01); A61M 2016/0027 (2013.01); A61M 2016/0036 (2013.01); A61M 16/0833 (2014.02); A61M 2205/054 (2013.01); A61M 2205/18 (2013.01); A61M 2205/505 (2013.01); A61M 2230/42 (2013.01); A61N 1/0551 (2013.01); A61N 1/08 (2013.01); A61N 1/3611 (2013.01)] | 38 Claims |

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[ 21. A percutaneous electrical phrenic nerve stimulation system comprising:
a lead system in electrical communication with a stimulator;
a controller circuit in operative communication with the lead system and stimulator; and
a graphical user interface (GUI) in operative communication with the controller circuit,
the controller circuit being configured to calculate work of breathing (WOB) for a patient-initiated breath detected via a flow sensor, the patient-initiated breath including one of an assist breath and a spontaneous breath such that the controller is configured to calculate at least one of an assist breath WOB and a spontaneous breath WOB based on lung compliance and resistance of the patient, and
the stimulator configured to deliver electrical stimulation via the lead system, the controller configured to cease the delivery of electrical stimulation from the stimulator if said at least one of the assist breath WOB and spontaneous breath WOB is above a desired level of WOB.]
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