US 12,272,980 B2
Neuromodulation apparatus, method and system
Rikky Muller, San Francisco, CA (US); Benjamin Johnson, Boise, ID (US); and Igor Izyumin, Oakland, CA (US)
Assigned to Nia Therapeutics, Inc., Boston, MA (US)
Filed by Nia Therapeutics, Inc., Radnor, PA (US)
Filed on Oct. 14, 2023, as Appl. No. 18/380,166.
Application 18/380,166 is a continuation of application No. 17/696,182, filed on Mar. 16, 2022, granted, now 11,791,645.
Application 17/696,182 is a continuation of application No. 16/317,538, granted, now 11,305,122, issued on Apr. 19, 2022, previously published as PCT/US2017/042043, filed on Jul. 14, 2017.
Claims priority of provisional application 62/510,380, filed on May 24, 2017.
Claims priority of provisional application 62/362,770, filed on Jul. 15, 2016.
Prior Publication US 2024/0039318 A1, Feb. 1, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/293 (2021.01); A61B 5/00 (2006.01); A61B 5/291 (2021.01); A61N 1/36 (2006.01); A61N 1/372 (2006.01); H02J 1/08 (2006.01); H02J 7/00 (2006.01); H02J 50/20 (2016.01)
CPC H02J 7/0063 (2013.01) [A61B 5/291 (2021.01); A61B 5/293 (2021.01); A61B 5/4836 (2013.01); A61B 5/6868 (2013.01); A61N 1/36125 (2013.01); A61N 1/36139 (2013.01); A61N 1/36157 (2013.01); A61N 1/36167 (2013.01); A61N 1/37223 (2013.01); H02J 1/082 (2020.01); H02J 7/00 (2013.01); A61B 5/4094 (2013.01); H02J 7/0025 (2020.01); H02J 50/20 (2016.02); H02J 2207/20 (2020.01)] 19 Claims
OG exemplary drawing
 
1. A system for electrical stimulation and electrical recording in human or non-human subject, the system comprising:
one or more implantable electrode arrays;
a first system controller configured to provide a plurality of stimulation parameters and a plurality of commands in response to received recorded data; and
one or more implantable apparatuses electromagnetically or wirelessly coupleable to the first system controller, each implantable apparatus coupled to a corresponding implantable electrode array comprising a plurality of electrodes, each implantable apparatus comprising:
a plurality of stimulation circuits selectively coupleable to the plurality of electrodes, each stimulation circuit configured, in response to a control signal of a first plurality of control signals, to provide a stimulation current on a selected electrode of the plurality of electrodes, each stimulation circuit comprising: a variable current source configured to generate a selectable, variable current to provide the stimulation current on the selected electrode; a first multiplexer coupled to each variable current source, the first multiplexer comprising a first plurality of switches; and a second multiplexer coupled to the first multiplexer, the second multiplexer comprising a second plurality of switches, each switch of the second multiplexer coupleable to a corresponding electrode of the plurality of electrodes;
a plurality of recording circuits, one or more recording circuits of the plurality of recording circuits configured to generate corresponding recorded data concurrently with the stimulation current;
a transceiver circuit coupled to the plurality of stimulation circuits and to the plurality of recording circuits, the transceiver circuit configured to transmit the corresponding recorded data to the first system controller and to receive the plurality of stimulation parameters and the plurality of commands from the first system controller for closed-loop feedback; and
a plurality of blocking circuits, each blocking circuit coupled to a corresponding recording circuit of the plurality of recording circuits and further coupleable to a corresponding electrode of the plurality of electrodes, each blocking circuit configured, in response to a corresponding control signal of a second plurality of control signals, to block the stimulation current on the selected electrode from the corresponding recording circuit.