US 12,270,781 B2
Electrochemical device for identifying electroactive analyte and related methods thereof
Cheng Yang, Lexington, MA (US); and B. Jill Venton, Charlottesville, VA (US)
Assigned to University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed by University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed on Jun. 23, 2022, as Appl. No. 17/847,532.
Application 17/847,532 is a continuation of application No. 16/348,916, granted, now 11,371,958, previously published as PCT/US2017/061091, filed on Nov. 10, 2017.
Claims priority of provisional application 62/422,320, filed on Nov. 15, 2016.
Prior Publication US 2023/0094625 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/327 (2006.01); H10K 85/20 (2023.01); B82Y 10/00 (2011.01); B82Y 15/00 (2011.01); B82Y 40/00 (2011.01)
CPC G01N 27/3278 (2013.01) [H10K 85/221 (2023.02); B82Y 10/00 (2013.01); B82Y 15/00 (2013.01); B82Y 40/00 (2013.01); G01N 27/327 (2013.01)] 37 Claims
OG exemplary drawing
 
1. An electrochemical device for identifying at least one electroactive analyte, said device comprising:
a substrate having a sampling end and a connection end of said substrate;
a sample region disposed at said sampling end of said substrate;
a counter electrode disposed in communication with said substrate, wherein said counter electrode having a sample end and a readout end, wherein a counter electrode longitudinal span is defined;
a reference electrode disposed in communication with said substrate, wherein said reference electrode having a sample end and a readout end, wherein a reference electrode longitudinal span is defined;
a working electrode disposed in communication with said substrate, wherein:
said working electrode having a sample end and a readout end, wherein a working electrode longitudinal span is defined, and
said working electrode comprises an electron conducting fiber;
a counter electrode channel, reference electrode channel, and working electrode channel are disposed in said substrate, wherein said counter electrode channel, said reference electrode channel, and said working electrode channel each form a recess disposed in said substrate;
wherein:
i) said counter electrode channel comprises:
a counter electrode distal neck channel in communication with said sample region located on said sample region toward the sampling end of said substrate, wherein said counter electrode distal neck channel forms a recess disposed in said substrate,
ii) said reference electrode channel comprises:
a reference electrode distal neck channel in communication with said sample region located on said sample region toward the sampling end of said substrate, wherein said reference electrode distal neck channel forms a recess disposed in said substrate, and
iii) said working electrode channel comprises:
a working electrode distal neck channel in communication with said sample region located on said sample region toward the sampling end of said substrate, wherein said working electrode distal neck channel forms a recess disposed in said substrate;
a conductive lead disposed in communication with each of respective readout ends of each of said counter electrode, reference electrode, and working electrode, wherein said conductive lead is configured to allow said counter electrode, reference electrode, and working electrode to communicate with a readout device or other ancillary coupling or transmission channel;
wherein each of respective sample ends of said counter electrode, reference electrode, and working electrode are partially disposed in said sample region configured to be exposed to the electroactive analyte; and
wherein said counter electrode channel, said reference electrode channel, and said working electrode channel are configured to:
receive the entire span of each of said counter electrode, said reference electrode, and said working electrode, respectively, for placement in each of said recesses of said respective electrode channels and said respective distal neck channels.