US 12,270,764 B2
Waveguide with outer coating for analyte detection
Arjen Boersma, Haaren (NL); Javier Nunez Villanueva, Eindhoven (NL); and Evert Jonathan Van Den Ham, Wijk en Aalburg (NL)
Assigned to Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO, 's-Gravenhage (NL)
Appl. No. 17/924,151
Filed by Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO, 's-Gravenhage (NL)
PCT Filed May 12, 2021, PCT No. PCT/NL2021/050311
§ 371(c)(1), (2) Date Nov. 9, 2022,
PCT Pub. No. WO2021/230748, PCT Pub. Date Nov. 18, 2021.
Claims priority of application No. 20174969 (EP), filed on May 15, 2020.
Prior Publication US 2023/0184686 A1, Jun. 15, 2023
Int. Cl. G01N 21/77 (2006.01); C03C 25/106 (2018.01); G02B 6/10 (2006.01); G02B 6/12 (2006.01)
CPC G01N 21/7703 (2013.01) [C03C 25/1061 (2018.01); G02B 6/10 (2013.01); G01N 2021/7716 (2013.01); G01N 2430/00 (2013.01); G02B 2006/12035 (2013.01); G02B 2006/12138 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method of manufacturing an optical sensing element, for detecting an analyte in a fluid medium, the method comprising:
providing an optical waveguide comprising an optically transparent material that essentially consists of a metal halide for guiding light through the sensing element;
depositing an inorganic coating that essentially consists of an inorganic material for adsorbing the analyte from the fluid medium; and
depositing, prior to depositing the inorganic coating, an adhesion promotion material or precursor thereof, onto the optically transparent material, to form an inorganic adhesion promotion layer that essentially consists of a metalloid, a metal, a metal oxide, a metalloid oxide, or mixtures thereof for promoting adhesion of the inorganic material.