US 12,269,900 B2
Inhibitors of β integrin-G protein α subunit binding interactions
Xiaoping Du, Willowbrook, IL (US)
Assigned to The Board of Trustees of the University of Illinois, Urbana, IL (US)
Filed by THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Filed on Aug. 7, 2020, as Appl. No. 16/988,287.
Application 16/988,287 is a continuation of application No. 15/986,470, filed on May 22, 2018, granted, now 10,738,080.
Application 15/986,470 is a continuation of application No. 14/843,152, filed on Sep. 2, 2015, granted, now 10,011,634.
Application 14/843,152 is a continuation of application No. 14/176,930, filed on Feb. 10, 2014, granted, now 9,156,884.
Application 14/176,930 is a continuation of application No. 13/621,064, filed on Sep. 15, 2012, granted, now 8,685,921.
Application 13/621,064 is a continuation in part of application No. PCT/US2011/028567, filed on Mar. 15, 2011.
Claims priority of provisional application 61/433,037, filed on Jan. 14, 2011.
Claims priority of provisional application 61/314,027, filed on Mar. 15, 2010.
Prior Publication US 2021/0054026 A1, Feb. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 7/06 (2006.01); A61K 38/08 (2019.01); A61K 47/69 (2017.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 7/06 (2013.01) [A61K 38/08 (2013.01); A61K 47/6909 (2017.08); C07K 14/4722 (2013.01); C07K 14/70546 (2013.01); C07K 14/70557 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01)] 23 Claims
 
1. A six-mer peptide consisting of the amino acid sequence
Phe Xaa1 Xaa2 Glu Xaa3 Xaa4
wherein Xaa1 is Glu and Xaa2 is Glu or Lys,
wherein Xaa3 is Lys or Arg and Xaa4 is Met or Leu,
and
wherein the peptide inhibits a binding interaction between a β integrin and a G protein α subunit.