US 12,269,874 B2
Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof
Takeshi Urano, Izumo (JP); Yuko Nariai, Izumo (JP); Hiroki Kamino, Izumo (JP); and Eiji Obayashi, Izumo (JP)
Assigned to mAbProtein Co., Ltd., Shimane (JP)
Appl. No. 17/264,479
Filed by mAbProtein Co., Ltd., Izumo (JP)
PCT Filed Dec. 3, 2019, PCT No. PCT/JP2019/047154
§ 371(c)(1), (2) Date Jan. 29, 2021,
PCT Pub. No. WO2020/116423, PCT Pub. Date Jun. 11, 2020.
Claims priority of application No. 2018-226667 (JP), filed on Dec. 3, 2018; and application No. 2019-104826 (JP), filed on Jun. 4, 2019.
Prior Publication US 2021/0317200 A1, Oct. 14, 2021
Int. Cl. C07K 16/24 (2006.01); G01N 33/53 (2006.01)
CPC C07K 16/244 (2013.01) [G01N 33/53 (2013.01); C07K 2317/32 (2013.01); C07K 2317/565 (2013.01); G01N 2333/54 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An anti-IL-18 monoclonal antibody comprising: a heavy chain variable region, wherein the heavy chain variable region comprises:
a CDR1H region consisting of the amino acid sequence of SEQ ID NO: 24,
a CDR2H region consisting of the amino acid sequence of SEQ ID NO: 25, and
a CDR3H region consisting of the amino acid sequence of SEQ ID NO: 26; and
a light chain variable region, wherein the light chain variable region comprises:
a CDR1L region consisting of the amino acid sequence of SEQ ID NO: 27,
a CDR2L region consisting of the amino acid sequence of SEQ ID NO: 28, and
a CDR3L region consisting of the amino acid sequence of SEQ ID NO: 29.