US 12,269,849 B2
Factor H binding protein variants and methods of use thereof
Peter T. Beernink, Walnut Creek, CA (US)
Assigned to Children's Hospital & Research Center at Oakland, Oakland, CA (US)
Filed by Children's Hospital & Research Center at Oakland, Oakland, CA (US)
Filed on Oct. 24, 2023, as Appl. No. 18/493,141.
Application 16/288,760 is a division of application No. 15/327,346, granted, now 10,266,572, issued on Apr. 23, 2019, previously published as PCT/US2015/041616, filed on Jul. 22, 2015.
Application 18/493,141 is a continuation of application No. 17/065,386, filed on Oct. 7, 2020, granted, now 11,834,476.
Application 17/065,386 is a continuation of application No. 16/600,259, filed on Oct. 11, 2019, granted, now 10,836,799, issued on Nov. 17, 2020.
Application 16/600,259 is a continuation of application No. 16/288,760, filed on Feb. 28, 2019, granted, now 10,487,122, issued on Nov. 26, 2019.
Claims priority of provisional application 62/028,123, filed on Jul. 23, 2014.
Prior Publication US 2024/0101610 A1, Mar. 28, 2024
Int. Cl. A61K 39/095 (2006.01); A61K 39/00 (2006.01); C07K 14/22 (2006.01)
CPC C07K 14/22 (2013.01) [A61K 39/00 (2013.01); A61K 39/095 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/575 (2013.01)] 10 Claims
 
1. A variant factor H binding protein (fHbp) comprising
an amino acid substitution of the glutamine at amino acid 38 (Q38),
wherein the amino acid substitution at Q38 is Q38R, Q38K, Q38H, Q38F, Q38Y, or Q38W,
wherein the amino acid substitution is relative to the amino acid sequence set forth in SEQ ID NO: 1, and
wherein the variant fHbp comprises an amino acid sequence at least 85% identical to the entire length of the amino acid sequence set forth in SEQ ID NO:1.