US 12,269,838 B2
Composition of mannuronic diacid
Meiyu Geng, Shanghai (CN); Jian Ding, Shanghai (CN); Zhenqing Zhang, Suzhou (CN); Zhongping Xiao, Shanghai (CN); Xiaoguang Du, Shanghai (CN); and Xianliang Xin, Shanghai (CN)
Assigned to GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., Shanghai (CN); and SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai (CN)
Filed by GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD., Shanghai (CN); and SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai (CN)
Filed on Jul. 8, 2022, as Appl. No. 17/860,468.
Application 17/860,468 is a continuation of application No. 16/474,928, granted, now 11,384,111, previously published as PCT/CN2017/118843, filed on Dec. 27, 2017.
Claims priority of application No. PCT/CN2016/113879 (WO), filed on Dec. 30, 2016.
Prior Publication US 2022/0356202 A1, Nov. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 15/04 (2006.01); A61K 31/7032 (2006.01); A61K 31/715 (2006.01); A61P 25/28 (2006.01); C08B 37/00 (2006.01)
CPC C07H 15/04 (2013.01) [A61K 31/7032 (2013.01); A61K 31/715 (2013.01); A61P 25/28 (2018.01); C08B 37/0084 (2013.01)] 17 Claims
 
1. A mannuronic diacid saccharide composition, comprising a mixture of mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1,
and wherein,
the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition; and
the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5; and
the total weight of mannuronic diacids wherein m+m′=1 and 2 is equal to or greater than 50% of the total weight of the composition.