US 12,269,826 B1
7H-pyrido[4′,3′:4,5]pyrrolo[2,3-c][1,7]naphthyridine compounds as CK2 inhibitors
Michelyne Haroun, Al-Ahsa (SA); and Christophe Tratrat, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Nov. 16, 2023, as Appl. No. 18/511,318.
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/22 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01)
CPC C07D 471/22 (2013.01) [A61P 35/00 (2018.01); A61P 35/02 (2018.01)] 8 Claims
 
1. A compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, or stereoisomer thereof, wherein:
R is -phenyl substituted with one or more substituents independently selected from the group consisting of —NR1R2, —CF3, —NHCOR1, a straight or branched C1-C6 alkyl, —CONR1R2, halogen, —SO2NR1R2, and —OR1; a pyridyl group substituted with a methyl, and a —CH2phenyl group substituted with a chlorine; and
R1 and R2 are independently a straight chain C1-C6 alkyl group or wherein R1 and R2 are taken together with the nitrogen atom to which they are attached to form a nitrogen-containing heterocycle, such nitrogen-containing heterocycle being optionally substituted with a straight or branched C1-C6 alkyl group.