US 12,269,808 B2
Amino dithioperacid thioester compound, preparation method therefor, and use thereof
Weili Zhao, Shanghai (CN); Xiongwen Zhang, Shanghai (CN); Xiaochun Dong, Shanghai (CN); Yiwei Li, Shanghai (CN); Shuang Xu, Shanghai (CN); Shanshan Lu, Shanghai (CN); Guangyu Lin, Shanghai (CN); and Kedan Gu, Shanghai (CN)
Assigned to FUDAN UNIVERSITY, Shanghai (CN); and EAST CHINA NORMAL UNIVERSITY, Shanghai (CN)
Appl. No. 17/786,159
Filed by FUDAN UNIVERSITY, Shanghai (CN); and EAST CHINA NORMAL UNIVERSITY, Shanghai (CN)
PCT Filed Nov. 27, 2020, PCT No. PCT/CN2020/132332
§ 371(c)(1), (2) Date Jun. 16, 2022,
PCT Pub. No. WO2021/121012, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 201911318067.9 (CN), filed on Dec. 19, 2019; and application No. 202011100806.X (CN), filed on Oct. 15, 2020.
Prior Publication US 2022/0396557 A1, Dec. 15, 2022
Int. Cl. C07D 295/21 (2006.01); A61P 21/00 (2006.01); C07D 205/04 (2006.01); C07D 207/12 (2006.01); C07D 207/16 (2006.01); C07D 209/08 (2006.01); C07D 209/44 (2006.01); C07D 295/194 (2006.01); C07D 295/195 (2006.01); C07D 491/107 (2006.01)
CPC C07D 295/21 (2013.01) [A61P 21/00 (2018.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 207/16 (2013.01); C07D 209/08 (2013.01); C07D 209/44 (2013.01); C07D 295/194 (2013.01); C07D 295/195 (2013.01); C07D 491/107 (2013.01)] 8 Claims
 
1. A carbamo (dithioperoxo) thioate compound of formula l:

OG Complex Work Unit Chemistry
or its pharmaceutically acceptable salt thereof, wherein,
m=1-11, X is a nitrogen-containing aliphatic heterocycle and the nitrogen atom in the aliphatic heterocycle is connected to the carbon atom of the thiocarbonyl group, wherein the nitrogen-containing aliphatic heterocycle is selected from pyrrolidine, morpholine, piperazine, indoline, isoindolin, octahydro-1H-indole, octahydro-1H-isoindole, azetidine and 2-oxa-6-azaspiro[3.4]octane.