US 12,269,807 B2
Crystalline forms of eravacycline
Danny LaFrance, Natick, MA (US); Philip C. Hogan, Brighton, MA (US); Yansheng Liu, Winchester, MA (US); Minsheng He, Andover, MA (US); Chi-Li Chen, Newton, MA (US); and John Niu, Bedford, MA (US)
Assigned to Tetraphase Pharmaceuticals, Inc., Waltham, MA (US)
Filed by Tetraphase Pharmaceuticals, Inc., Waltham, MA (US)
Filed on Jan. 5, 2023, as Appl. No. 18/093,569.
Application 18/093,569 is a continuation of application No. 17/188,063, filed on Mar. 1, 2021, granted, now 11,578,044.
Application 17/188,063 is a continuation of application No. 16/342,779, granted, now 10,961,190, previously published as PCT/US2017/057385, filed on Oct. 19, 2017.
Claims priority of provisional application 62/410,230, filed on Oct. 19, 2016.
Prior Publication US 2023/0416212 A1, Dec. 28, 2023
Int. Cl. C07D 295/15 (2006.01); A61P 31/04 (2006.01); C07D 207/06 (2006.01)
CPC C07D 295/15 (2013.01) [A61P 31/04 (2018.01); C07D 207/06 (2013.01); C07B 2200/13 (2013.01)] 17 Claims
 
1. A crystalline form of the bis-HCl salt of a compound represented by Structural Formula 1:

OG Complex Work Unit Chemistry
wherein
the crystalline form is Form I and is characterized by at least three x-ray powder diffraction peaks at 2θ angles selected from 7.22°, 7.80°, 10.41°, and 11.11°.
 
10. A crystalline form of the bis-HCl salt of a compound represented by Structural Formula 1:

OG Complex Work Unit Chemistry
wherein
the crystalline form is Form J and is characterized by at least three x-ray powder diffraction peaks at 2θ angles selected from 7.02°, 7.80°, 22.13°, and 23.22°.
 
16. A composition, comprising particles of one or more crystalline forms of a compound represented by the bis HCl salt of Structural Formula 1:

OG Complex Work Unit Chemistry
wherein the one or more crystalline forms are selected from:
the particles are of crystalline Form I characterized by at least three x-ray powder diffraction peaks at 2θ angles selected from 7.22°, 7.80°, 10.41°, and 11.11°; and
the particles are of crystalline form Form J characterized by at least three x-ray powder diffraction peaks at 2θ angles selected from 7.02°, 7.80°, 22.13°, and 23.22°.